Effective Immunization with Live Attenuated Influenza A Virus Can Be Achieved in Early Infancy
Identifieur interne : 001C32 ( Main/Exploration ); précédent : 001C31; suivant : 001C33Effective Immunization with Live Attenuated Influenza A Virus Can Be Achieved in Early Infancy
Auteurs : Mary Lou Clements [États-Unis] ; Mamodikoe K. Makhene [États-Unis] ; Ruth A. Karron [États-Unis] ; Brian R. Murphy [États-Unis] ; Mark C. Steinhoff [États-Unis] ; Kanta Subbarao [États-Unis] ; Modena H. Wilson [États-Unis] ; Pediatric Care Center [États-Unis] ; Peter F. Wright [États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1996.
Abstract
The immunogenicity of vaccines can be modified in infancy by maternal antibodies and other immunizations. Hence, the safety and immunogenicity of two doses of 107 TCID50 of live, attenuated cold-adapted (ca) influenza A/Kawasaki/86 (H1N1) reassortant virus vaccine given with or apart from childhood immunizations were evaluated in infants, starting at 2, 4, or >6 months of age, in randomized, double-blind trials. The ca vaccine was safe and did not significantly reduce the immunogenicity of the childhood vaccines in these infants. Infectivity of ca virus (virus shedding, ⩾4-fold rise in serum hemagglutination inhibition antibody titer, or both) was affected by age, quantity of ca virus given, and prior ca virus infection. Two doses of 107 TCID50 of ca influenza virus infected all infants, indicating that both doses are probably needed to achieve immunity against influenza in infants <6 months of age.
Url:
DOI: 10.1093/infdis/173.1.44
Affiliations:
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Broadway, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Makhene, Mamodikoe K" sort="Makhene, Mamodikoe K" uniqKey="Makhene M" first="Mamodikoe K." last="Makhene">Mamodikoe K. Makhene</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Immunization Research, Department of International Health, School of Public Health, and Departments of Medicine and Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, Bethesda, Maryland, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Karron, Ruth A" sort="Karron, Ruth A" uniqKey="Karron R" first="Ruth A." last="Karron">Ruth A. Karron</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Immunization Research, Department of International Health, School of Public Health, and Departments of Medicine and Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, Bethesda, Maryland, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Immunization Research, Department of International Health, School of Public Health, and Departments of Medicine and Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, Bethesda, Maryland, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Steinhoff, Mark C" sort="Steinhoff, Mark C" uniqKey="Steinhoff M" first="Mark C." last="Steinhoff">Mark C. Steinhoff</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Immunization Research, Department of International Health, School of Public Health, and Departments of Medicine and Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, Bethesda, Maryland, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Immunization Research, Department of International Health, School of Public Health, and Departments of Medicine and Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, Bethesda, Maryland, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Wilson, Modena H" sort="Wilson, Modena H" uniqKey="Wilson M" first="Modena H." last="Wilson">Modena H. 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Wright</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Center for Immunization Research, Department of International Health, School of Public Health, and Departments of Medicine and Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, Bethesda, Maryland, Nashville</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1996-01">1996</date><biblScope unit="vol">173</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="44">44</biblScope><biblScope unit="page" to="51">51</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The immunogenicity of vaccines can be modified in infancy by maternal antibodies and other immunizations. Hence, the safety and immunogenicity of two doses of 107 TCID50 of live, attenuated cold-adapted (ca) influenza A/Kawasaki/86 (H1N1) reassortant virus vaccine given with or apart from childhood immunizations were evaluated in infants, starting at 2, 4, or >6 months of age, in randomized, double-blind trials. The ca vaccine was safe and did not significantly reduce the immunogenicity of the childhood vaccines in these infants. Infectivity of ca virus (virus shedding, ⩾4-fold rise in serum hemagglutination inhibition antibody titer, or both) was affected by age, quantity of ca virus given, and prior ca virus infection. Two doses of 107 TCID50 of ca influenza virus infected all infants, indicating that both doses are probably needed to achieve immunity against influenza in infants <6 months of age.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Clements, Mary Lou" sort="Clements, Mary Lou" uniqKey="Clements M" first="Mary Lou" last="Clements">Mary Lou Clements</name></region><name sortKey="Center, Pediatric Care" sort="Center, Pediatric Care" uniqKey="Center P" first="Pediatric Care" last="Center">Pediatric Care Center</name><name sortKey="Clements, Mary Lou" sort="Clements, Mary Lou" uniqKey="Clements M" first="Mary Lou" last="Clements">Mary Lou Clements</name><name sortKey="Karron, Ruth A" sort="Karron, Ruth A" uniqKey="Karron R" first="Ruth A." last="Karron">Ruth A. Karron</name><name sortKey="Makhene, Mamodikoe K" sort="Makhene, Mamodikoe K" uniqKey="Makhene M" first="Mamodikoe K." last="Makhene">Mamodikoe K. Makhene</name><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name><name sortKey="Steinhoff, Mark C" sort="Steinhoff, Mark C" uniqKey="Steinhoff M" first="Mark C." last="Steinhoff">Mark C. Steinhoff</name><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><name sortKey="Wilson, Modena H" sort="Wilson, Modena H" uniqKey="Wilson M" first="Modena H." last="Wilson">Modena H. Wilson</name><name sortKey="Wright, Peter F" sort="Wright, Peter F" uniqKey="Wright P" first="Peter F." last="Wright">Peter F. Wright</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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